Space Ghost Coast to Coast is an American live-action/adult animated hybrid television series created by Mike Lazzo for Cartoon Network and first broadcast in 1994. It takes the form of a surreal parody of talk shows, hosted by a reimagined version of the Hanna-Barbera character Space Ghost. It incorporates surrealism and non-sequitur humor.

Space Ghost Coast to Coast is the first TV show produced by Williams Street (formerly known as Ghost Planet Industries), which started Adult Swim in the early 2000s. It contrasts the original 1960s series, Space Ghost, which aired as a standard Hanna-Barbera Saturday-morning superhero cartoon.

Space Ghost Coast to Coast is one of the first original series produced for Cartoon Network, and the earliest not to broadcast pre-existing cartoons. It premiered on April 15, 1994, and originally ended on December 17, 1999. It was revived on May 7, 2001, and was moved to the new Adult Swim late-night programming block on September 2, where new episodes premiered until April 12, 2004. Two final seasons were released exclusively on GameTap from 2006 to 2008. 109 episodes were aired over 11 seasons.

Space Ghost Coast to Coast helped launch the careers of the animators Adam Reed, Matt Thompson, Andy Merrill, Jim Fortier, Pete Smith, Michael Ouweleen, Erik Richter, Dave Willis, and Matt Maiellaro. It produced the spin-offs The Brak Show, Aqua Teen Hunger Force, Perfect Hair Forever, and Harvey Birdman, Attorney at Law. The series inspired or influenced other series for Adult Swim, including Sealab 2021 and The Eric Andre Show.