American Dad! is an American animated sitcom created by Seth MacFarlane, Mike Barker and Matt Weitzman for the Fox Broadcasting Company. The series premiered on February 6, 2005, following Super Bowl XXXIX, with the rest of the first season airing from May 1 of the same year. The show centers around the Smiths, a dysfunctional family consisting of parents Stan and Francine, their children, Hayley and Steve, as well as a goldfish named Klaus and an extraterrestrial named Roger. In the seventh season, Hayley's boyfriend (turned husband) Jeff Fischer ed the main cast, followed by Rogu, Roger's neoplastic son who ed in season fifteen. Unlike MacFarlane's other show, Family Guy, American Dad! does not lean as heavily on the use of cutaway gags, instead deriving its humor mostly from the quirky characters and their relationships.

The show was conceived by MacFarlane and Weitzman after the two were inspired by the 2000 United States presidential election, and Fox Broadcasting ordered a pilot presentation of the series in September 2003. American Dad! was the first series made specifically for Fox's Animation Domination block. The series moved to TBS for its twelfth season in 2014 until the conclusion of its twenty-first season in March 2025. It will return to Fox for its twenty-second season in early 2026 and was renewed through its twenty-fifth season on the network.

American Dad! has received generally positive reviews and has been nominated for numerous awards. In June 2013, it was awarded as top television series by the American Society of Composers, Authors and Publishers. It has also been nominated for four Primetime Emmy Awards and two Annie Awards.